Our research group is currently centered on understanding the nature of the dynamic ubiquitylation and deubiquitylation of the sliding clamp PCNA during S-phase in eukaryotic organisms. With the experience accumulated through years of work in the lab with budding and fission yeast models (see biographies), we strongly believe that we will soon understand the patterns of interactions and functionality of the ubiquitin-proteases that travel with the replisome during DNA synthesis in these unicellular organisms.
One of the research targets in the lab is the S.cerevisae UBP10 gene that encodes a nuclear (mainly nucleolar) protein with a role as a PCNA deubiquitylase (or PCNA-DUB)
